Topic outline
Main course page
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Facilitator: Assoc. Prof. Dr. Tan Eng Lai
Average minutes to complete this topic: 120 minutes and Case study 900 minutes
Stem cells undergo self-renewal and differentiate into multiple lineages of mature cells. The identification of stem cells in diverse adult tissues and the findings that human embryonic stem cells can be proliferated and differentiated has kindled the imagination of both scientists and the public regarding future stem cell technology. These cells could constitute an unlimited supply of diverse cell types that can be used for cell transplantation or drug discovery. The new options raise several fundamental ethical issues. This series of lectures gives an overview of the scientific basis underlying the hope generated by stem cell research and discusses current ethical and regulations stem cell therapy.
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The central dogma of molecular biology refers to the processes of gene expression. Each step of gene expression corresponds with a type of omic. For example, transcription corresponds with transcriptomic while translation corresponds to proteomic etc. In this section, we will briefly explain the processes of gene expression.
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Genetic variation and environmental factors lead to the diversity that we observe in each individual. In this section we will discuss about normal genetic variation that leads to normal phenotypic diversity and rare genetic variation that leads to diseases.
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