3. From Genome to Gene Function
Time: Lecture – 4 hrs, Project – 2 hrs, Case study– 15 hrs
The elucidation of genetic components of human diseases at the molecular level on a global scale provides crucial information for gene discovery, biomarker determination, disease classification, and drug target identification. This series of lectures will provide an overview of the current and emerging tools involved in genomic studies, including expression arrays, microRNA arrays, array CGH, ChIP-on-chip, methylation arrays, mutation analysis, proteomic analysis, integrated functional genomic analysis and related bioinformatics and biostatistical analyses. Various in vitro and in vivo models for disease and drug discovery will also be discussed and their ethical issues addressed in this series of lectures.