MM308 Molecular Basis of Diseases 2 (Trial)
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About This Module
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Ice Breaking Session
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One good way to get to know each each other is to post here some information about your self. This may include your educational background, your job, hobbies or your experiences in any area of interest.
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References
Giacca, M., Gene Therapy. 2010: Springer Milan. (Link: https://link.springer.com.ezp.imu.edu.my/book/10.1007/978-88-470-1643-9)
Clark, D.P., Molecular Biology. 2009, Burlington, UNITED STATES: Elsevier Science. (Link: https://ebookcentral.proquest.com/lib/imu-ebooks/detail.action?docID=269863)
Coskun, M., S. Vermeire, and O.H. Nielsen, Novel Targeted Therapies for Inflammatory Bowel Disease. Trends Pharmacol Sci, 2017. 38(2): p. 127-142. (Link: http://www.sciencedirect.com.ezp.imu.edu.my/science/article/pii/S0165614716301584)
Pokorski, M., Respiratory Regulation - The Molecular Approach. 2012: Springer Netherlands. (Link:https://link.springer.com.ezp.imu.edu.my/book/10.1007/978-94-007-4549-0)
Etzioni, A. and H.D. Ochs, Primary Immunodeficiency Disorders: A Historic and Scientific Perspective. 2014: Elsevier Science. (Link: http://www.sciencedirect.com.ezp.imu.edu.my/science/book/9780124071797)
Holt RI, Cockram C, Flyvbjerg A, Goldstein BJ, editors. Textbook of diabetes. John Wiley & Sons; 2010 Jul 9.http://onlinelibrary.wiley.com.ezp.imu.edu.my/book/10.1002/9781444324808?campaign=IMUmalaysia
Choquet, H., & Meyre, D. (2011). Molecular Basis of Obesity: Current Status and Future Prospects. Current Genomics, 12(3), 154–168. http://doi.org/10.2174/138920211795677921https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137001/
Barh D. Omics Approaches in Breast Cancer. https://link.springer.com.ezp.imu.edu.my/book/10.1007/978-81-322-0843-3
Chatterjee M, Kashfi K, editors. Cell signaling & molecular targets in cancer. Springer Science & Business Media; 2011 Dec 2. https://link.springer.com.ezp.imu.edu.my/book/10.1007/978-1-4614-0730-0
Trent, R.J., Molecular Medicine: Genomics to Personalized Healthcare. 2012: Elsevier Science. (Link: http://www.sciencedirect.com.ezp.imu.edu.my/science/book/9780123814517)
Yegnasubramanian, S. and W.B. Isaacs, Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research. 2010: Springer New York. (Link: https://link.springer.com.ezp.imu.edu.my/book/10.1007/978-0-387-69745-1)
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Topic Discussion
The Discussion Forum for each topic is parked under the respective topic sections. Please use the forum to post questions, discuss points of interest, share learning resources or even share your thoughts and suggestions related to the topic.
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Summative Assessment
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Students mustMark as done
This written scientific report will contribute 60% of total marks for this module.
Students are required to write a scientific report with approximate 3000 - 4000 words. The use of figures and tables to aid explanation is highly encouraged.
Instruction:
1. Choose a gastrointestinal/respiratory/immune/diabetes/endocrine/cancer/mental disease that you are interested in. Explain the epidemiological aspect of the disease.
2. Discuss the molecular and cellular pathways of this disease.
3. Discuss the current technology/methodology used to identify new molecular target and develop new treatment.
4. Identify the research gap of this disease (what important aspect is yet to be studied).
5. Propose an research idea to address the research gap mentioned above. Explain your rationale.
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Students mustMark as done
Based on the scientific report that you have prepared, prepare a 15 minutes presentation to present your research and idea to your peers and lecturers. This will be followed by a 5 - 10 minutes question and answer question. For ODL student, you need to record the video of your presentation and the Q&A session will be replaced by written response in Teams. For conventional student, this will be a sync session.
This presentation will account for 40% of the total marks for this module
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Welcome to Topic 1. The lecture and videos here will serve as an introduction to the basics of molecular pathways involved in different disease conditions. This lecture will provide knowledge about different types of receptors and drug-receptor interactions, and the receptor target identification methods. The correlation of genetics, basic physiology and pathology and its influence on molecular resistance, diagnostics, treatment and translational research will be dealt with.
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Learning Materials
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Students mustMark as done
This lecture will give you an overview of molecular basis of diseases with introduction of some important basic concepts.
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Students mustMark as done
This is a Youtube video, developed by Haptares Therapeutics, on structure elucidation of GPCRs and how drugs targeting the receptors may be developed or designed.
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Students mustMark as done
This is the link to a Youtube video, developed by Illumina, on incorporating medical genomics into clinical practice.
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Students mustMark as done
This link brings you to a video giving an overview of the concept of precision medicine with examples explained.
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Students mustMark as done
This is the link to a Youtube video, developed by Time, on the promise and problem with the use of precision medicine.
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Learning Activities
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Welcome to Topic 2. There will be several i-lectures and videos covering various topics on gastrointestinal diseases (as listed below).
You will be required to go through these topics, and engage yourselves in an online discussion under 'Ongoing Discussion' section.
Please note that your participation in the 'Ongoing Discussion' will be used as proof of your attendance. -
This link will bring you to a Youtube video on immunology in the gut. It provides an overview of the immunological processes and mechanisms in human gut.
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This is a Youtube video developed by Osmosis.org on causes, symptoms, pathology and treatment for ulcerative colitis.
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This is a Youtube video developed by Osmosis.org on causes, symptoms and pathology for Crohn's disease.
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This is a Youtube video developed by Nucleus Medical Media on pathogenesis and treatment for peptic ulcer.
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This i-lecture provides an overview of the pathphysiological processes that occur in irritable bowel diseases including Crohn's disease and ulcerative colitis.
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This i-lecture provides you with updates on current and emerging therapies for irritable bowel diseases.
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This i-lecture provides an overview of pathophysiology of peptic ulcers and acid-related disorders where the role of Helicobactor pylori as an etiological factor will be discussed.
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This i-lecture provides an overview of treatment for acid-related disorders with focus on Helicobacter pylori eradication.
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This is the lecture note covering the i-lectures and video lectures listed above.
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Knowledge Check Activity
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Students mustMake attempts: 1
Please attempt the questions here to help you better understand the content of i-lectures and videos for this topic.
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Students mustViewMake forum posts: 1
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