Introduction to molecular basis of diseases 1 (Lecture- 1 hr)

Faculty-in-Charge: Dr. Mayuren Candasamy

This is a lecture outlining the basics of molecular diseases, including molecular biology, drug/receptor interactions, receptors and ion channels, regulation of second messengers, and drug metabolism. The correlation of genetics, basic physiology and pathology and its influence on molecular resistance, diagnostics, treatment and translational research will be dealt with.

Functional basis of molecular diseases (Lectures- 2 hrs)

Faculty-in-Charge: Dr. Mayuren Candasamy

The lectures deal with dose response curves, knowledge regarding various molecular models of drug-receptor interaction like Molecular Models of Drug-Receptor Interaction including heterotrimeric and ternary complexes and operational model of drug action and various mechanisms of efficacy that include direct agonism, stimulus response mechanisms, estimation of agonist efficacy and indirect agonism. This will help students to understand the practicalities involved in the functional pharmacology which include different methods employed for measurement and comparison of drug response and various pre-requisites for the acquisition of reliable data.